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SmartPeptide discussions
native, moderated, evidence-firstSURMOUNT-1 (NEJM 2022, ~2,500 participants without diabetes) reported up to ~22.5% body-weight reduction at 72 weeks on the 15mg dose vs ~2.4% placebo. Dual GIP/GLP-1 agonism appears to outperform GLP-1-only on weight outcomes. Open questions: muscle mass preservation, long-term cardiovascular endpoints.
STEP-1 (NEJM 2021, ~2,000 participants, 68 weeks) found semaglutide 2.4mg/week produced ~14.9% body-weight reduction vs ~2.4% placebo. Side effects: GI (nausea, diarrhea) most common, usually subsiding after dose escalation. What it didn't measure well: long-term metabolic adaptation after stopping. Anyone here on it long-term?