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Fat Loss·SmartPeptide·5/7/2026
Semaglutide: what STEP-1 actually showed (plain English)
STEP-1 (NEJM 2021, ~2,000 participants, 68 weeks) found semaglutide 2.4mg/week produced ~14.9% body-weight reduction vs ~2.4% placebo. Side effects: GI (nausea, diarrhea) most common, usually subsiding after dose escalation. What it didn't measure well: long-term metabolic adaptation after stopping. Anyone here on it long-term?