SmartPeptide

Peptide Library

Searchable, scored, and cited. Every peptide page pulls live data from institutional sources (FDA, NIH, EMBL-EBI). Browse by goal below or filter by evidence quality.

Educational only — not medical advice. SmartPeptide does not prescribe, diagnose, or treat. Always consult a licensed healthcare provider before using any peptide, supplement, medication, or protocol.

10 results· filtered by diabetes / glycemic Clear all filters

Semaglutide

Fat Loss
Strong

GLP-1 receptor agonist with extensive Phase 3 trial data for type 2 diabetes and chronic weight management. Prescription-only in most jurisdictions.

Research
95
Popular
99
Smart
97

Tirzepatide

Fat Loss
Strong

Dual GIP / GLP-1 receptor agonist with strong Phase 3 evidence in type 2 diabetes (SURPASS) and obesity (SURMOUNT).

Research
92
Popular
95
Smart
93

Retatrutide

Fat Loss
Limited

Eli Lilly's triple agonist (GLP-1 / GIP / glucagon receptor). Currently the most potent weight-management investigational drug — Phase 2 trials reported ~24% body weight reduction at the highest dose. Phase 3 TRIUMPH program ongoing. Not yet FDA-approved.

Research
82
Popular
92
Smart
85

Liraglutide

Fat Loss
Strong

Daily GLP-1 receptor agonist (Saxenda/Victoza). FDA-approved for chronic weight management and type 2 diabetes. Older sibling of semaglutide with smaller weight-loss effect size.

Research
90
Popular
70
Smart
84

Orforglipron

Fat Loss
Limited

Eli Lilly's once-daily ORAL non-peptide GLP-1 receptor agonist (LY3502970). The first oral small-molecule GLP-1 with no food/water restrictions (unlike Rybelsus). Phase 3 ACHIEVE program for diabetes and ATTAIN for obesity both ongoing.

Research
70
Popular
75
Smart
72

Tesamorelin

Fat Loss
Strong

GHRH analog (Egrifta) FDA-approved for HIV-associated lipodystrophy. Studied for visceral adiposity reduction outside that indication.

Research
75
Popular
45
Smart
68

CJC-1295 / Ipamorelin

Muscle
Limited

Growth-hormone secretagogue combination studied for stimulating endogenous GH pulses in research contexts.

Research
40
Popular
80
Smart
56

IGF-1 LR3

Muscle
Preclinical

Insulin-like Growth Factor 1, Long R3 variant — an analog of human IGF-1 with extended half-life (~20-30 hours vs. ~12 minutes for native IGF-1). Used in research; widely (and controversially) discussed in performance-enhancement communities. NOT FDA-approved for human use; the only approved IGF-1 product is mecasermin (native sequence).

Research
30
Popular
70
Smart
38

MOTS-c

Longevity
Preclinical

Mitochondrial-derived peptide encoded in the 12S rRNA. Preclinical data on insulin sensitivity, exercise capacity, and metabolic health. No FDA approval. Human data limited to small studies.

Research
30
Popular
55
Smart
35

5-Amino-1MQ

Fat Loss
Preclinical

Small-molecule NNMT inhibitor (NOT a peptide — it's a quinoline derivative). NNMT (nicotinamide N-methyltransferase) is upregulated in obese white adipose tissue. Preclinical studies show 5-Amino-1MQ reduces adipocyte size and improves metabolic markers in obese mice. No human RCTs. Sold as a research chemical.

Research
18
Popular
60
Smart
28