TB-500
Synthetic fragment related to thymosin beta-4. Investigated in animal studies for cellular migration and tissue remodeling.
Educational only — not medical advice. SmartPeptide does not prescribe, diagnose, or treat. Always consult a licensed healthcare provider before using any peptide, supplement, medication, or protocol.
What the research shows
Animal studies suggest cellular migration and tissue remodeling effects, especially in cardiac and dermal wound models.
What's still experimental
Human efficacy is essentially unproven. Safety profile in humans is undocumented in peer-reviewed RCTs.
Anecdotal / community reports
Athletic recovery claims are common in community forums but not supported by published human trials.
Anecdotal reports are NOT scientific evidence. They reflect personal experience and may not generalize.
Live research
Updated hourly · sourced from PubMed + ClinicalTrials.govClinical trials (ClinicalTrials.gov)
- A Phase 1 Safety Study of the Intravenous Administration of Thymosin Beta in Healthy VolunteersWITHDRAWNNCT00743769 · PHASE1 · 2008-04
- Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2RECRUITINGNCT05555589 · PHASE3 · n=70 · 2023-04-11
- A Phase 1a Study of Thymosin Beta 4 in Healthy VolunteersCOMPLETEDNCT04555824 · PHASE1 · n=54 · 2017-07-17
- A Study of the Safety and Efficacy of Injectable Thymosin Beta 4 for Treating Acute Myocardial InfarctionWITHDRAWNNCT01311518 · PHASE2 · 2019-07
- TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVDRECRUITINGNCT07487363 · PHASE1, PHASE2 · n=80 · 2026-02-05
Known risks
Almost no human clinical data. Banned in competitive sport (WADA).
Reported side effects
Limited human safety reporting; theoretical immunomodulation concerns.
What requires medical supervision
Banned in competitive sport (WADA). Not approved for human use in most countries. Clinical supervision required if used at all.
Questions for your clinician
- Is there any human safety data we can review?
- Could this interact with my current medications?
- What objective markers would we follow if we tried this?