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Kisspeptin

Neuropeptide encoded by the KISS1 gene. Master regulator of the hypothalamic-pituitary-gonadal axis — stimulates GnRH release and downstream LH/FSH/sex-hormone production. Studied as a diagnostic and therapeutic agent for hypogonadism, infertility, and sexual function. Not FDA-approved.

Educational only — not medical advice. SmartPeptide does not prescribe, diagnose, or treat. Always consult a licensed healthcare provider before using any peptide, supplement, medication, or protocol.

What the research shows

Multiple small academic clinical trials (mostly Imperial College London) demonstrate kisspeptin restores LH pulsatility in hypothalamic amenorrhea, modulates sexual brain activity, and shows promise as a diagnostic for reproductive disorders. Therapeutic dosing protocols and approved formulations do not yet exist.

What's still experimental

Optimal therapeutic dosing, route, and chronic-use safety. Use in male hypogonadism, female fertility, and sexual function outside research settings.

Anecdotal / community reports

Limited grey-market presence; mostly academic-research interest. Anecdotal claims for libido / sexual function exist but are unsupported by approved labeling.

Anecdotal reports are NOT scientific evidence. They reflect personal experience and may not generalize.

FDA approval status

Source: openFDA + DailyMed (NIH/NLM)
No FDA-approved drug label exists for “Kisspeptin”. This peptide is not currently approved by the FDA as a finished pharmaceutical product. Any commercial product claiming FDA approval should be treated with suspicion.

Doses studied in research

No established dose range

What published trials tested or FDA-approved labels specify. Reporting research facts — not a SmartPeptide recommendation.

No FDA-approved or established trial dose range for this peptide. Anecdotal ranges discussed in community forums exist but are not supported by published clinical trials, and SmartPeptide will not publish unverified doses.

This is the honest answer for peptides like BPC-157, IGF-1 LR3, MOTS-c, Epitalon and similar research compounds — robust human dose- ranging studies have not been published. Always work with a licensed clinician familiar with experimental peptides if you are considering any use.

FDA enforcement & recalls

Live · openFDA Drug Enforcement API
No FDA enforcement actions (recalls, market withdrawals, safety alerts) on record for “Kisspeptin”. This is the expected baseline for most peptides — the absence of recalls does NOT imply general safety, only that no formal FDA enforcement has been initiated against approved formulations.

Mechanism & targets

ChEMBL · UniProt · Open Targets

Molecule (ChEMBL)

View on ChEMBL

Protein targets (UniProt)

  • Metastasis-suppressor KiSS-1
    Q15726gene: KISS1Homo sapiens· 138 aaReviewed

    Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (PubMed:11385580, PubMed:11457843, PubMed:11527393, PubMed:12879005, PubMed:15020672, PubMed:15596153). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15219839, PubMed:15598687, PubMed:22335740). In these neurons, kisspeptin binding to it…

  • Metastasis-suppressor KiSS-1
    Q6Y4S4gene: Kiss1Mus musculus· 130 aaReviewed

    Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (By similarity). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15217982, PubMed:15486019, PubMed:15375028, PubMed:15665093, PubMed:17563351). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leadin…

  • Metastasis-suppressor KiSS-1
    Q7TSB7gene: Kiss1Rattus norvegicus· 130 aaReviewed

    Kisspeptins are ligands for the G protein-coupled receptor KISS1R/GPR54 (By similarity). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:15219839, PubMed:15242985, PubMed:15500545, PubMed:15637288, PubMed:17698953). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leadin…

Live research

PubMed · ClinicalTrials.gov · Europe PMC · OpenAlex
PubMed papers
3,817
total
Human studies
0
MeSH: humans
Clinical trials
0
published
Active trials
9
45 total registered

Clinical trials (ClinicalTrials.gov)

All trials for "kisspeptin"

Europe PMC — 7,544 additional records

Includes EU/UK studies and PubMed Central full-text articles. Often surfaces research weeks before PubMed indexes it.

Research volume (OpenAlex topic graph)

Total works
14,368
all years
Last 5 years
7,162
recent activity
Open access
11,460
freely readable
OA share
80%
of all works

Human clinical evidence

Semantic Scholar · AI TLDRs · influence-ranked
Semantic Scholar API is currently rate-limited.

Human-study summaries for “kisspeptin” are available on Semantic Scholar but the shared free-tier API quota is exhausted right now. Try refreshing in a few minutes, or check the PubMed and Europe PMC panels above for the same literature.

Research funding & verification

NIH RePORTER · CrossRef DOI registry

NIH-funded research

U.S. National Institutes of Health
Funded projects
659
all years
Top award sum
$35.8M
aggregate USD
Years covered
20
research span
Largest active / recent grants

Publication landscape

CrossRef · DOI registry
Indexed works (CrossRef)
2,901
all DOIs registered
Retracted papers
0
no retractions on record
Top funders of indexed research
  • National Natural Science Foundation of China51 works
  • National Institutes of Health50 works
  • Japan Society for the Promotion of Science29 works
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development22 works
  • Biotechnology and Biological Sciences Research Council22 works
  • Medical Research Council19 works

Funder diversity is a credibility signal. Research concentrated in a single drug company's funding warrants more scrutiny than research funded across NIH, charities, and academic grants.

Preprints — cutting edge

bioRxiv · medRxiv · via Europe PMC

Preprints have NOT been peer-reviewed. They are early research shared by authors before formal validation. Treat findings as preliminary.

Showing 6 of 123 preprints indexed by Europe PMC.

Known risks

Most studied as short-duration infusions in controlled clinical settings. Long-term safety with chronic dosing is unestablished. Theoretical concerns about reproductive-axis dysregulation. Pregnancy and breast/prostate cancer interactions need careful consideration.

Reported side effects

Generally well-tolerated in short clinical-trial settings: mild headache, transient flushing. Long-term tolerability poorly characterized.

FDA adverse event reports (FAERS)

Updated quarterly by FDA
Reports filed
1
FAERS, all years
Serious reports
1
100% of reports
Top reporting countries
  • US1

Most-reported reactions

  • Oestrone Increased
    1
  • Weight Increased
    1

Counts from FDA Adverse Event Reporting System (FAERS). Voluntary reports — they show what was reported, not whether the drug caused the event. Many reports lack confirmation. FAERS docs

What requires medical supervision

Restricted to clinical research. Patients with reproductive endocrine concerns should work with reproductive endocrinologists using established FDA-approved options.

Questions for your clinician

  • Is there a clinical trial appropriate for my situation?
  • What FDA-approved options should we exhaust first?
  • What's the evidence base for the specific outcome I'm hoping for?

Editorially curated references

Discussions about Kisspeptin

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