Educational only — not medical advice. SmartPeptide does not prescribe, diagnose, or treat. Always consult a licensed healthcare provider before using any peptide, supplement, medication, or protocol.
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Side Effects·SmartPeptide·5/7/2026
Tirzepatide and muscle loss — what the evidence says
A common worry on GLP-1/GIP agonists is lean mass loss along with fat. SURMOUNT body-comp sub-analyses suggest the proportion of lean mass loss is roughly similar to lifestyle-only weight loss, but absolute lean loss can be larger because total loss is bigger. Resistance training + adequate protein (1.6-2.2g/kg) appears protective.